| http://purl.uniprot.org/citations/17500071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17500071 | http://www.w3.org/2000/01/rdf-schema#comment | "Secreted Frizzled-related protein-1 (sFRP-1) belongs to a class of extracellular antagonists that modulate Wnt signaling pathways by preventing ligand-receptor interactions among Wnts and Frizzled membrane receptor complexes. sFRP-1 and Wnts are heparin-binding proteins, and their interaction can be stabilized by heparin in vitro. Here we report that heparin can specifically enhance recombinant sFRP-1 accumulation in a cell type-specific manner. The effect requires O-sulfation in heparin, and involves fibroblast growth factor-2 as well as fibroblast growth factor receptor-1. Interestingly, further investigation uncovers that heparin can also affect the post-translational modification of sFRP-1. We demonstrate that sFRP-1 is post-translationally modified by tyrosine sulfation at tyrosines 34 and 36, which is inhibited by the treatment of heparin. The results suggest that accumulation of sFRP-1 induced by heparin is in part due to the relative stabilization of unsulfated sFRP-1 and the direct stabilization by heparin. The study has revealed a multifaceted regulation on sFRP-1 protein by heparin."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m609096200"xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Bhat R.A."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Stahl M."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Kriz R."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Presman E."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Pocas J."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Bodine P."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/author | "Desilva T."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/pages | "20523-20533"xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/title | "Regulation of secreted Frizzled-related protein-1 by heparin."xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17500071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17500071 |
| http://purl.uniprot.org/citations/17500071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17500071 |
| http://purl.uniprot.org/uniprot/P09038#attribution-F467B30D80664A67E840A3D1DA98DD4D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17500071 |
| http://purl.uniprot.org/uniprot/Q8N474#attribution-F467B30D80664A67E840A3D1DA98DD4D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17500071 |
| http://purl.uniprot.org/uniprot/#_A8KAM5-mappedCitation-17500071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17500071 |
| http://purl.uniprot.org/uniprot/#_Q8N474-mappedCitation-17500071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17500071 |
| http://purl.uniprot.org/uniprot/#_Q05DS5-mappedCitation-17500071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17500071 |
| http://purl.uniprot.org/uniprot/#_Q6ZSL4-mappedCitation-17500071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17500071 |