| http://purl.uniprot.org/citations/17502602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17502602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17502602 | http://www.w3.org/2000/01/rdf-schema#comment | "Null mutations in the IL1-receptor accessory protein-like 1 gene (IL1RAPL1) are responsible for an inherited X-linked form of cognitive impairment. IL1RAPL1 protein physically interacts with neuronal calcium sensor-1 (NCS-1), but the functional impact of the IL1RAPL1/NCS-1 interaction remains unknown. Here, we demonstrate that stable expression of IL1RAPL1 in PC12 cells induces a specific silencing of N-type voltage-gated calcium channels (N-VGCC) activity that explains a secretion deficit observed in these IL1RAPL1 cells. Importantly, this modulation of VGCC activity is mediated by NCS-1. Indeed, a specific loss-of-function of N-VGCC was observed in PC12 cells overexpressing NCS-1, and a total recovery of N-VGCC activity was obtained by a down-regulation of NCS-1 in IL1RAPL1 cells. The functional relevance of the interaction between IL1RAPL1 and NCS-1 was also suggested by the reduction of neurite elongation observed in nerve growth factor (NGF)-treated IL1RAPL1 cells, a phenotype rescued by NCS-1 inactivation. Because both proteins are highly expressed in neurons, these results suggest that IL1RAPL1-related mental retardation could result from a disruption of N-VGCC and/or NCS-1-dependent synaptic and neuronal activities."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0701133104"xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0701133104"xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Chelly J."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Chelly J."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Poulain B."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Poulain B."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Skala H."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Skala H."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Vitale N."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Vitale N."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Dupont J.-L."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Dupont J.-L."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Bahi N."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Bahi N."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Begle A."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Begle A."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Courjaret R."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Courjaret R."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Gambino F."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Gambino F."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Gardette R."xsd:string |
| http://purl.uniprot.org/citations/17502602 | http://purl.uniprot.org/core/author | "Gardette R."xsd:string |