| http://purl.uniprot.org/citations/17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17504809 | http://www.w3.org/2000/01/rdf-schema#comment | "Wrch-1 (Wnt-regulated Cdc42 homolog) is a new member of the Rho family that was identified as a gene transcriptionally upregulated by Wnt-1. Wrch-1 has no detectable GTPase activity and displays very high intrinsic guanine nucleotide exchange, implying that it is constitutively GTP-bound. The biological functions of Wrch-1 largely remain to be characterized. Here, we report that Wrch-1 prominently localizes to focal adhesions. Depletion of Wrch-1 by small interfering RNA increases focal adhesion formation, whereas Wrch-1 overexpression disassembles focal adhesions. Wrch-1 depletion inhibits myosin-light-chain phosphorylation, which in turn leads to an increase in the number of focal adhesions and inhibits cell migration in response to wound healing. Depletion of Wrch-1 also inhibits Akt and JNK activation. Although pharmacological inhibitors of Akt and JNK inhibit cell migration, they do not affect focal adhesions. Thus, our data suggest that Wrch-1 regulates cell migration by multiple mechanisms: on the one hand Wrch-1 controls focal adhesions by regulating myosin light chain and on the other hand Wrch-1 stimulates the activation of Akt and JNK."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03456"xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/author | "Backer J.M."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/author | "Symons M."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/author | "Chuang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/author | "Coniglio S.J."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/author | "Valster A."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/pages | "1927-1934"xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/title | "The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration."xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17504809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17504809 |
| http://purl.uniprot.org/citations/17504809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17504809 |
| http://purl.uniprot.org/uniprot/#_Q14155-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_Q14161-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_Q15052-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_Q13153-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_Q13177-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_O00308-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_P27986-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
| http://purl.uniprot.org/uniprot/#_O75886-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |
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| http://purl.uniprot.org/uniprot/#_P16333-mappedCitation-17504809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17504809 |