| http://purl.uniprot.org/citations/17506725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17506725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17506725 | http://www.w3.org/2000/01/rdf-schema#comment | "CgNa (Condylactis gigantea neurotoxin) is a 47-amino-acid-residue toxin from the giant Caribbean sea anemone Condylactis gigantea. The structure of CgNa, which was solved by 1H-NMR spectroscopy, is somewhat atypical and displays significant homology with both type I and II anemone toxins. CgNa also displays a considerable number of exceptions to the canonical structural elements that are thought to be essential for the activity of this group of toxins. Furthermore, unique residues in CgNa define a characteristic structure with strong negatively charged surface patches. These patches disrupt a surface-exposed cluster of hydrophobic residues present in all anemone-derived toxins described to date. A thorough characterization by patch-clamp analysis using rat DRG (dorsal root ganglion) neurons indicated that CgNa preferentially binds to TTX-S (tetrodotoxin-sensitive) voltage-gated sodium channels in the resting state. This association increased the inactivation time constant and the rate of recovery from inactivation, inducing a significant shift in the steady state of inactivation curve to the left. The specific structural features of CgNa may explain its weaker inhibitory capacity when compared with the other type I and II anemone toxins."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20070130"xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20070130"xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Beress L."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Beress L."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Jimenez-Barbero J."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Jimenez-Barbero J."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Gimenez-Gallego G."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Gimenez-Gallego G."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Lopez O."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Lopez O."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Lopez-Mendez B."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Lopez-Mendez B."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Forssmann W.-G."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Forssmann W.-G."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Soto E."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Soto E."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Garateix A."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Garateix A."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Salceda E."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Salceda E."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Standker L."xsd:string |
| http://purl.uniprot.org/citations/17506725 | http://purl.uniprot.org/core/author | "Standker L."xsd:string |