| http://purl.uniprot.org/citations/17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17507554 | http://www.w3.org/2000/01/rdf-schema#comment | "Nicotinic acetylcholine receptors (nAChRs) contribute significantly to hippocampal function. Alpha7-nAChRs are present in presynaptic sites in hippocampal neurons and may influence transmitter release, but the factors that determine their presynaptic localization are unknown. We report here that Wnt-7a, a ligand active in the canonical Wnt signaling pathway, induces dissociation of the adenomatous polyposis coli (APC) protein from the beta-catenin cytoplasmic complex and the interaction of APC with alpha7-nAChRs in hippocampal neurons. Interestingly, Wnt-7a induces the relocalization of APC to membranes, clustering of APC in neurites, and coclustering of APC with different, presynaptic protein markers. Wnt-7a also increases the number and size of coclusters of alpha7-nAChRs and APC in presynaptic terminals. These short-term changes in alpha7-nAChRs occur in the few minutes after ligand exposure and involve translocation to the plasma membrane without affecting total receptor levels. Longer-term exposure to Wnt-7a increases nAChR alpha7 subunit levels in an APC-independent manner and increases clusters of alpha7-nAChRs in neurites via an APC-dependent process. Together, these results demonstrate that stimulation through the canonical Wnt pathway regulates the presynaptic localization of APC and alpha7-nAChRs with APC serving as an intermediary in the alpha7-nAChR relocalization process. Modulation by Wnt signaling may be essential for alpha7-nAChR expression and function in synapses."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3934-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Inestrosa N.C."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Lukas R.J."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Godoy J.A."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Farias G.G."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Toledo E.M."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Barrantes F.J."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Colombres M."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/author | "Valles A.S."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/pages | "5313-5325"xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/title | "Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17507554 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17507554 |
| http://purl.uniprot.org/citations/17507554 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17507554 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K8G0-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K5T5-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |
| http://purl.uniprot.org/uniprot/#_P70478-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZR24-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZXW5-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |
| http://purl.uniprot.org/uniprot/#_A6IB96-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |
| http://purl.uniprot.org/uniprot/#_G3V8Q9-mappedCitation-17507554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17507554 |