| http://purl.uniprot.org/citations/17509016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17509016 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to increase the understanding of the role of serotonergic signalling in normal gastroduodenal function at a molecular level. Mucosal biopsy specimens were collected from the fundus, antrum and duodenum of 11 healthy subjects. Serotonin (5-HT)-positive cells were counted and the mRNA levels of tryptophan hydroxylase (TPH), serotonin transporter (SERT), 5-HT(4) receptor and 5-HT(3) receptor subunits were quantified by real-time reverse transcription polymerase chain reaction. The number of 5-HT-positive cells was larger in the duodenum compared with the stomach (P < 0.001). Serotonin transport protein expression was 19-fold higher in the duodenum compared with the antrum and 457-fold higher compared with the fundus (P < 0.001). Tryptophan hydroxylase-1 expression was lower in the duodenum compared with the antrum and fundus (regional differences -2.3 and -3.6, respectively). The 5-HT(4) receptor and the 5-HT(3C) and 5-HT(3E) receptor subunits were more abundantly expressed in duodenum compared with the stomach (P < 0.001). The larger number of 5-HT-positive cells, the higher expression of 5-HT(3) and 5-HT(4) receptors, and in particularly the higher uptake capacity of 5-HT in the duodenum, point out to a more prominent role of serotonergic signalling at the mucosal level in the duodenum compared with the stomach."xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2982.2006.00891.x"xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/author | "Ter Linde J."xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/author | "Samsom M."xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/author | "Schipper M.E."xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/author | "van Lelyveld N."xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/name | "Neurogastroenterol Motil"xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/pages | "342-348"xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/title | "Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum."xsd:string |
| http://purl.uniprot.org/citations/17509016 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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