Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17509577http://www.w3.org/2000/01/rdf-schema#comment"

Study objective

To assess the relationship between first-trimester maternal serum PAPP-A and free beta-hCG and birth weight.

Design

Observational study.

Setting

Teaching hospital.

Patient(s)

Singleton pregnancies (n = 1,630) at 10-14 weeks of gestation.

Intervention(s)

Fluorimetric immunoassays for maternal serum pregnancy-associated plasma protein A (PAPP-A) and free beta-hCG.

Main outcome measure(s)

Customized birth weight percentiles, calculated taking into account maternal height, weight, ethnic origin, parity, smoking status, and fetal gender.

Result(s)

There was a significant positive correlation between birth weight and PAPP-A, but not free beta-hCG levels. Maternal serum levels of PAPP-A were significantly lower in small-for-gestation (SGA) newborns than in control subjects and were significantly higher in large-for-gestation (LGA) newborns than in control subjects. Maternal serum free beta-hCG levels were lower in pregnancies complicated by pre-eclampsia than in normotensive ones. Multivariable analysis found PAPP-A to be an independent predictor of absolute birth weight, SGA, and LGA. Free beta-hCG was found to be an independent predictor of gestational hypertension and pre-eclampsia. Neither of the two markers was associated with preterm delivery.

Conclusion(s)

Maternal serum PAPP-A levels in the late first trimester of pregnancy are associated with subsequent fetal growth (including both physiologic variation and abnormal growth), and decreased free beta-hCG is more predictive of hypertensive disorders of pregnancy."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.org/dc/terms/identifier"doi:10.1016/j.fertnstert.2007.02.024"xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"Crocetti L."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"Prefumo F."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"Venturini P.L."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"Canini S."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"De Biasio P."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"Pastorino D."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/author"Afflitto C.G."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/name"Fertil Steril"xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/pages"174-178"xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/title"Association between birth weight and first-trimester free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A."xsd:string
http://purl.uniprot.org/citations/17509577http://purl.uniprot.org/core/volume"89"xsd:string
http://purl.uniprot.org/citations/17509577http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17509577
http://purl.uniprot.org/citations/17509577http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17509577
http://purl.uniprot.org/uniprot/#_B4DTA7-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/#_B4DTA8-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/#_Q13219-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/#_Q5QFB7-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/#_Q86YM8-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/#_Q7Z613-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/#_Q8IWT8-mappedCitation-17509577http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17509577
http://purl.uniprot.org/uniprot/Q86YM8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17509577
▶