| http://purl.uniprot.org/citations/17510063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17510063 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) signaling is controlled by a variety of regulators that target either signaling receptors or activated Smad complexes. Among the negative regulators, Smad7 antagonizes TGF-beta signaling mainly through targeting the signaling receptors, whereas SnoN and c-Ski repress signaling at the transcriptional level through inactivation of Smad complexes. We previously found that Arkadia is a positive regulator of TGF-beta signaling that induces ubiquitin-dependent degradation of Smad7 through its C-terminal RING domain. We report here that Arkadia induces degradation of SnoN and c-Ski in addition to Smad7. Arkadia interacts with SnoN and c-Ski in their free forms as well as in the forms bound to Smad proteins, and constitutively down-regulates levels of their expression. Arkadia thus appears to effectively enhance TGF-beta signaling through simultaneous down-regulation of two distinct types of negative regulators, Smad7 and SnoN/c-Ski, and may play an important role in determining the intensity of TGF-beta family signaling in target cells."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701294200"xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Fujii T."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Nagano Y."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Imamura T."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Lee K.L."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Saitoh M."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Yuki K."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Miyazawa K."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Episkopou V."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Mavrakis K.J."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Koinuma D."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Isogaya K."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/author | "Sase H."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/pages | "20492-20501"xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/title | "Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling."xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17510063 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17510063 |
| http://purl.uniprot.org/citations/17510063 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17510063 |
| http://purl.uniprot.org/uniprot/P12757#attribution-E103B175586635C8720A9928D315EF95 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17510063 |
| http://purl.uniprot.org/uniprot/P12755#attribution-E103B175586635C8720A9928D315EF95 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17510063 |