| http://purl.uniprot.org/citations/17510365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17510365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17510365 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation of beta-catenin, the key effector of the WNT signaling pathway, results in stabilization of beta-catenin and, in turn, activation of transcription. We have used tandem-affinity protein purification and mass spectrometry to define the protein interaction network of the beta-catenin destruction complex. This assay revealed that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC (adenomatous polyposis coli). Functional analyses in cultured cells, Xenopus, and zebrafish demonstrate that WTX promotes beta-catenin ubiquitination and degradation, which antagonize WNT/beta-catenin signaling. These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.org/dc/terms/identifier | "doi:10.1126/science/1141515"xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.org/dc/terms/identifier | "doi:10.1126/science/1141515"xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Gingras A.C."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Gingras A.-C."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Gingras A.-C."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Zheng N."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Zheng N."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Yi X."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Yi X."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Angers S."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Angers S."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Berndt J.D."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Berndt J.D."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Biechele T.L."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Biechele T.L."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Camp N.D."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Camp N.D."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Goldenberg S.J."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Goldenberg S.J."xsd:string |
| http://purl.uniprot.org/citations/17510365 | http://purl.uniprot.org/core/author | "Hubbert C."xsd:string |