| http://purl.uniprot.org/citations/17510388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17510388 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogene DJ-1 has been associated with multiple cancers, including prostate cancer, where it can be stabilized by androgens and antiandrogens. However, little data exist on the expression pattern and function of DJ-1 in prostate cancer. To address the function of DJ-1 in prostate, a yeast two-hybrid screen was done to identify novel DJ-1 binding proteins. The androgen receptor (AR) was identified and confirmed as a DJ-1 binding partner. This is the first evidence that DJ-1 directly interacts with AR. We also show that modulation of DJ-1 expression regulated AR transcriptional activity. Importantly, both the subcellular localization of DJ-1 and the interaction with AR are regulated by androgens and antiandrogens. Additionally, immunohistochemical staining on two human prostate cancer tissue arrays was done providing the first large-scale expression analysis of DJ-1 in prostate. DJ-1 expression did not change with Gleason pattern but increased after androgen deprivation therapy, indicating that it may be involved in the development of androgen independence. These data provide a novel mechanism where DJ-1-mediated regulation of AR may promote the progression of prostate cancer to androgen independence."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-4556"xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Rennie P.S."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Ghosh R."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Fazli L."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Gleave M."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Gu G."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Kasper S."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Flynt A.S."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/author | "Tillman J.E."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/pages | "4630-4637"xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/title | "DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17510388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17510388 |
| http://purl.uniprot.org/citations/17510388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17510388 |
| http://purl.uniprot.org/uniprot/Q99497#attribution-46700D66721BB0C26ACC7DC05BC8A181 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17510388 |
| http://purl.uniprot.org/uniprot/Q99497#attribution-B0FFBBF1E58C27B059CC3DB82EA8CBA6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17510388 |
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| http://purl.uniprot.org/uniprot/#_Q99497-mappedCitation-17510388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17510388 |
| http://purl.uniprot.org/uniprot/Q99497 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17510388 |
| http://purl.uniprot.org/uniprot/P10275 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17510388 |