| http://purl.uniprot.org/citations/17510705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17510705 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelial progenitor cell (EPC) transplantation has beneficial effects for therapeutic neovascularization; however, only a small proportion of injected cells home to the lesion and incorporate into the neocapillaries. Consequently, this type of cell therapy requires substantial improvement to be of clinical value. Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and their ephrin ligands are key regulators of vascular development. We postulated that activation of the EphB4/ephrin-B2 system may enhance EPC proangiogenic potential. In this report, we demonstrate in a nude mouse model of hind limb ischemia that EphB4 activation with an ephrin-B2-Fc chimeric protein increases the angiogenic potential of human EPCs. This effect was abolished by EphB4 siRNA, confirming that it is mediated by EphB4. EphB4 activation enhanced P selectin glycoprotein ligand-1 (PSGL-1) expression and EPC adhesion. Inhibition of PSGL-1 by siRNA reversed the proangiogenic and adhesive effects of EphB4 activation. Moreover, neutralizing antibodies to E selectin and P selectin blocked ephrin-B2-Fc-stimulated EPC adhesion properties. Thus, activation of EphB4 enhances EPC proangiogenic capacity through induction of PSGL-1 expression and adhesion to E selectin and P selectin. Therefore, activation of EphB4 is an innovative and potentially valuable therapeutic strategy for improving the recruitment of EPCs to sites of neovascularization and thereby the efficiency of cell-based proangiogenic therapy."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci28338"xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Souttou B."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Plouet J."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Levy B.I."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Silvestre J.S."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Contreres J.O."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Tobelem G."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Sulpice E."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Ebrahimian T.G."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Barateau V."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Foubert P."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Le Ricousse-Roussanne S."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/author | "Lere-Dean C."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/pages | "1527-1537"xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/title | "PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/17510705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17510705 |
| http://purl.uniprot.org/citations/17510705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17510705 |
| http://purl.uniprot.org/uniprot/#_B4DVT5-mappedCitation-17510705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17510705 |
| http://purl.uniprot.org/uniprot/#_Q62128-mappedCitation-17510705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17510705 |