| http://purl.uniprot.org/citations/17512407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17512407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17512407 | http://www.w3.org/2000/01/rdf-schema#comment | "ZAP-70, a cytoplasmic tyrosine kinase required for T cell antigen receptor signaling, is controlled by a regulatory segment that includes a tandem SH2 unit responsible for binding to immunoreceptor tyrosine-based activation motifs (ITAMs). The crystal structure of autoinhibited ZAP-70 reveals that the inactive kinase domain adopts a conformation similar to that of cyclin-dependent kinases and Src kinases. The autoinhibitory mechanism of ZAP-70 is, however, distinct and involves interactions between the regulatory segment and the hinge region of the kinase domain that reduce its flexibility. Two tyrosine residues in the SH2-kinase linker that activate ZAP-70 when phosphorylated are involved in aromatic-aromatic interactions that connect the linker to the kinase domain. These interactions are inconsistent with ITAM binding, suggesting that destabilization of this autoinhibited ZAP-70 conformation is the first step in kinase activation."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.03.039"xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.03.039"xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Kuriyan J."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Kuriyan J."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Brdicka T."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Kadlecek T.A."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Kadlecek T.A."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Deindl S."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/author | "Deindl S."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/pages | "735-746"xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/pages | "735-746"xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/title | "Structural basis for the inhibition of tyrosine kinase activity of ZAP-70."xsd:string |
| http://purl.uniprot.org/citations/17512407 | http://purl.uniprot.org/core/title | "Structural basis for the inhibition of tyrosine kinase activity of ZAP-70."xsd:string |