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http://purl.uniprot.org/citations/17513705http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17513705http://www.w3.org/2000/01/rdf-schema#comment"

Objective

A major goal in genetic studies of type 1A diabetes is prediction of anti-islet autoimmunity and subsequent diabetes in the general population, as >85% of patients do not have a first-degree relative with type 1A diabetes. Given prior association studies, we hypothesized that the strongest candidates for enhancing diabetes risk among DR3-DQB1*0201/DR4-DQB1*0302 individuals would be alleles of DP and DRB1*04 subtypes and, in particular, the absence of reportedly protective alleles DPB1*0402 and/or DRB1*0403.

Research design and methods

We genotyped 457 DR3-DQB1*0201/DR4-DQB1*0302 Diabetes Autoimmunity Study of the Young (DAISY) children (358 general population and 99 siblings/offspring of type 1 diabetic patients) at the DPB1, DQB1, and DRB1 loci using linear arrays of immobilized sequence-specific oligonucleotides, with direct sequencing to differentiate DRB1*04 subtypes.

Results

By survival curve analysis of DAISY children, the risk of persistently expressing anti-islet autoantibodies is approximately 55% for relatives (children with a parent or sibling with type 1 diabetes) in the absence of these two protective alleles vs. 0% (P = 0.02) with either protective allele, and the risk is 20 vs. 2% (P = 0.004) for general population children. Even when the population analyzed is limited to DR3-DQB1*0201/DR4-DQB1*0302 children with DRB1*0401 (the most common DRB1*04 subtype), DPB1*0402 influences development of anti-islet autoantibodies.

Conclusions

The ability to identify a major group of general population newborns with a 20% risk of anti-islet autoimmunity should enhance both studies of the environmental determinants of type 1A diabetes and the design of trials for the primary prevention of anti-islet autoimmunity."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.org/dc/terms/identifier"doi:10.2337/db07-0029"xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Yu L."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Norris J.M."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Noble J.A."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Miao D."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Eisenbarth G.S."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Erlich H.A."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Fernando M.S."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Babu S.R."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Rewers M.J."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Aly T.A."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Barriga K.J."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/author"Baschal E.E."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/name"Diabetes"xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/pages"2405-2409"xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/title"HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population."xsd:string
http://purl.uniprot.org/citations/17513705http://purl.uniprot.org/core/volume"56"xsd:string
http://purl.uniprot.org/citations/17513705http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17513705
http://purl.uniprot.org/citations/17513705http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17513705
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17513705http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17513705
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17513705http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17513705
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17513705http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17513705
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