| http://purl.uniprot.org/citations/17516030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17516030 | http://www.w3.org/2000/01/rdf-schema#comment | "CDK11(p58), a G2/M-specific protein kinase, has been shown to be associated with apoptosis in many cell lines, with largely unknown mechanisms. Our previous study proved that CDK11(p58)-enhanced cycloheximide (CHX)-induced apoptosis in SMMC-7721 hepatocarcinoma cells. Here we report for the first time that ectopic expression of CDK11(p58) down-regulates Bcl-2 expression and its Ser70, Ser87 phosphorylation in CHX-induced apoptosis in SMMC-7721 cells. Overexpression of Bcl-2 counteracts the pro-apoptotic activity of CDK11(p58). Furthermore, we confirm that the kinase activity of CDK11(p58) is essential to the down-regulation of Bcl-2 as well as apoptosis. Taken together, these results demonstrate that CDK11(p58) down-regulates Bcl-2 in pro-apoptosis pathway depending on its kinase activity, which elicits survival signal in hepatocarcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-007-9502-x"xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Yao L."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Yun X."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/author | "Zong H."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/pages | "213-218"xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/title | "CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway."xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/17516030 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17516030 |
| http://purl.uniprot.org/citations/17516030 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17516030 |
| http://purl.uniprot.org/uniprot/Q9UK58#attribution-2B22D6ED70605EBD8A550F15B56832ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17516030 |
| http://purl.uniprot.org/uniprot/Q52KE7#attribution-2B22D6ED70605EBD8A550F15B56832ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17516030 |
| http://purl.uniprot.org/uniprot/Q96S94#attribution-2B22D6ED70605EBD8A550F15B56832ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17516030 |
| http://purl.uniprot.org/uniprot/P24788#attribution-2B22D6ED70605EBD8A550F15B56832ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17516030 |
| http://purl.uniprot.org/uniprot/P21127#attribution-2B22D6ED70605EBD8A550F15B56832ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17516030 |
| http://purl.uniprot.org/uniprot/Q9UQ88#attribution-2B22D6ED70605EBD8A550F15B56832ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17516030 |