| http://purl.uniprot.org/citations/17516545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17516545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17516545 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid inducible gene-I (RIG-I) functions as the first line of defense against viral infection by sensing dsRNA and inducing type I interferon (IFN) production. The expression of RIG-I itself is induced by IFN-alpha/beta and dsRNA. To comprehend the molecular mechanism of expression regulation, we cloned the RIG-I promoter and analyzed its activity upon IFN-beta and dsRNA treatment. Under basal condition, RIG-I mRNA level and promoter activity were significantly higher in normal cells versus their tumor counterparts. In both normal and cancer cells, RIG-I expression was induced by IFN-beta and dsRNA. A single IRF-1 binding site in the proximal promoter functioned as a crucial regulator of basal, IFN-beta- and dsRNA-mediated induction of the RIG-I promoter. IFN-beta and dsRNA treatment increased IRF-1 binding to the RIG-I promoter. IRF-1 expression was also higher in normal cells than in cancer cells and it was induced by IFN-beta with similar kinetics as RIG-I. These results confirm that by controlling RIG-I expression, IRF-1 plays an essential role in anti-viral immunity. IRF-1 is a tumor suppressor and the expression profile of RIG-I together with its regulation by IRF-1 and the presence of a caspase-recruitment domain in RIG-I suggest that RIG-I might also possess tumor suppressor properties."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21128"xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.21128"xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Su Z.Z."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Su Z.Z."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Emdad L."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Emdad L."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Barral P.M."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/author | "Barral P.M."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/name | "J. Cell. Physiol."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/name | "J. Cell. Physiol."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/pages | "502-510"xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/pages | "502-510"xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/title | "Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/title | "Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression."xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/17516545 | http://purl.uniprot.org/core/volume | "213"xsd:string |