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http://purl.uniprot.org/citations/17520389http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17520389http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the mRNA levels of Kiss-1 and KAI-1 metastasis suppressor genes in gastric cancer, and to explore its clinical value.

Methods

In situ hybridization was used on routinely paraffin-embedded sections of resected specimens of 49 cases with gastric cancer and 20 cases with pericancerous tissue.

Results

The positive rates and the scores of Kiss-1 and KAI-1 mRNA in gastric cancer tissue were significantly lower than those in pericancerous tissue (P<0.01). The positive rates and scores in normal to mild-atypical hyperplasia cases were significantly higher than those in middle to severe-atypical hyperplasia of pericancerous tissue (P<0.05,P<0.01). The positive rates and scores of Kiss-1 and KAI-1 mRNA in patients with infiltrating depth T1~T2, without lymph node metastasis, with only first group of lymph node metastasis, and without distant organ metastasis were significantly higher than those in patients with infiltrating depth T3~T4, with lymph node metastasis, with second or third group of lymph node metastasis and with distant organ metastasis. A strong positive correlation was found between the expressive scores of Kiss-1 and KAI-1 mRNA in gastric cancer (r=0.53, P<0.01).

Conclusion

The expression of Kiss-1 and/or KAI-1 mRNA may be important biological markers of reflecting invasive and metastatic potential and prognosis in gastric cancer. The assays of Kiss-1 and/or KAI-1 mRNA expression level in benign lesions of stomach may have important clinical value for the protection and early-stage finding of gastric cancer."xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/author"Yang Z.L."xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/author"Li Y.G."xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/author"Liu G.W."xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/author"Yao H.L."xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/name"Zhonghua Wei Chang Wai Ke Za Zhi"xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/pages"274-277"xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/title"[In situ hybridization study on the expression of Kiss-1 and KAI-1 metastasis suppressor genes in gastric cancer]."xsd:string
http://purl.uniprot.org/citations/17520389http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/17520389http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17520389
http://purl.uniprot.org/citations/17520389http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17520389
http://purl.uniprot.org/uniprot/#_Q15726-mappedCitation-17520389http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17520389
http://purl.uniprot.org/uniprot/#_P27701-mappedCitation-17520389http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17520389
http://purl.uniprot.org/uniprot/#_Q6LET0-mappedCitation-17520389http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17520389
http://purl.uniprot.org/uniprot/Q15726http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17520389
http://purl.uniprot.org/uniprot/P27701http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17520389
http://purl.uniprot.org/uniprot/Q6LET0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17520389