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| http://purl.uniprot.org/citations/17521570 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptotagmin-1 and -2 are known Ca(2+) sensors for fast synchronous neurotransmitter release, but the potential Ca(2+)-sensor functions of other synaptotagmins in release remain uncharacterized. We now show that besides synaptotagmin-1 and -2, only synaptotagmin-9 (also called synaptotagmin-5) mediates fast Ca(2+) triggering of release. Release induced by the three different synaptotagmin Ca(2+) sensors exhibits distinct kinetics and apparent Ca(2+) sensitivities, suggesting that the synaptotagmin isoform expressed by a neuron determines the release properties of its synapses. Conditional knockout mice producing GFP-tagged synaptotagmin-9 revealed that synaptotagmin-9 is primarily expressed in the limbic system and striatum. Acute deletion of synaptotagmin-9 in striatal neurons severely impaired fast synchronous release without changing the size of the readily-releasable vesicle pool. These data show that in mammalian brain, only synaptotagmin-1, -2, and -9 function as Ca(2+) sensors for fast release, and that these synaptotagmins are differentially expressed to confer distinct release properties onto synapses formed by defined subsets of neurons."xsd:string |
| http://purl.uniprot.org/citations/17521570 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.05.004"xsd:string |
| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/author | "Mashimo T."xsd:string |
| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
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| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/title | "Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons."xsd:string |
| http://purl.uniprot.org/citations/17521570 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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