| http://purl.uniprot.org/citations/17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17522201 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus type 1 (HIV-1) infection of individuals carrying the two alleles of the CCR5Delta32 mutation (CCR5(-/-)) has rarely been reported, but how the virus overcomes the CCR5Delta32 protective effect in these cases has not been delineated. We have investigated this in 6 infected (HIV(+)) and 25 HIV(-) CCR5(-/-) individuals. CD4(+) T lymphocytes isolated from HIV(-) CCR5(-/-) peripheral blood mononuclear cells (PBMCs) showed lower levels of CXCR4 expression that correlated with lower X4 Env-mediated fusion. Endogenous CCR5Delta32 protein was detected in all HIV(-) CCR5(-/-) PBMC samples (n = 25) but not in four of six unrelated HIV(+) CCR5(-/-) PBMC samples. Low levels were detected in another two HIV(+) CCR5(-/-) PBMC samples. The expression of adenovirus 5 (Ad5)-encoded CCR5Delta32 protein restored the protective effect in PBMCs from three HIV(+) CCR5(-/-) individuals but failed to restore the protective effect in PBMCs isolated from another three HIV(+) CCR5(-/-) individuals. In the latter samples, pulse-chase analyses demonstrated the disappearance of endogenous Ad5-encoded CCR5Delta32 protein and the accumulation of Ad5-encoded CCR5 during the chase periods. PBMCs isolated from CCR5(-/-) individuals showed resistance to primary X4 but were readily infected by a lab-adapted X4 strain. Low levels of Ad5-encoded CCR5Delta32 protein conferred resistance to primary X4 but not to lab-adapted X4 virus. These data provide strong support for the hypothesis that the CCR5Delta32 protein actively confers resistance to HIV-1 in vivo and suggest that the loss or reduction of CCR5Delta32 protein expression may account for HIV-1 infection of CCR5(-/-) individuals. The results also suggest that other cellular or virally induced factors may be involved in the stability of CCR5Delta32 protein."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00068-07"xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Jin Q."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Alkhatib G."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Meyer L."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Theodorou I."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Agrawal L."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Tubiana R."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/author | "Altenburg J."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/pages | "8041-8049"xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/title | "CCR5Delta32 protein expression and stability are critical for resistance to human immunodeficiency virus type 1 in vivo."xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17522201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17522201 |
| http://purl.uniprot.org/citations/17522201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G3K0-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |
| http://purl.uniprot.org/uniprot/#_A0A089G3N4-mappedCitation-17522201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17522201 |