| http://purl.uniprot.org/citations/17524417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17524417 | http://www.w3.org/2000/01/rdf-schema#comment | "CENP-A is a histone variant that replaces conventional H3 in nucleosomes of functional centromeres. We report here, from reconstitutions of CENP-A- and H3-containing nucleosomes on linear DNA fragments and the comparison of their electrophoretic mobility, that CENP-A induces some positioning of its own and some unwrapping at the entry-exit relative to canonical nucleosomes on both 5 S DNA and the alpha-satellite sequence on which it is normally loaded. This steady-state unwrapping was quantified to 7(+/-2) bp by nucleosome reconstitutions on a series of DNA minicircles, followed by their relaxation with topoisomerase I. The unwrapping was found to ease nucleosome invasion by exonuclease III, to hinder the binding of a linker histone, and to promote the release of an H2A-H2B dimer by nucleosome assembly protein 1 (NAP-1). The (CENP-A-H4)2 tetramer was also more readily destabilized with heparin than the (H3-H4)2 tetramer, suggesting that CENP-A has evolved to confer its nucleosome a specific ability to disassemble. This dual relative instability is proposed to facilitate the progressive clearance of CENP-A nucleosomes that assemble promiscuously in euchromatin, especially as is seen following CENP-A transient over-expression."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2007.04.064"xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/author | "Black B.E."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/author | "Cleveland D.W."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/author | "Filipski J."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/author | "Conde e Silva N."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/author | "Prunell A."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/author | "Sivolob A."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/pages | "555-573"xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/title | "CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization."xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://purl.uniprot.org/core/volume | "370"xsd:string |
| http://purl.uniprot.org/citations/17524417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17524417 |
| http://purl.uniprot.org/citations/17524417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17524417 |
| http://purl.uniprot.org/uniprot/#_A5HUM4-mappedCitation-17524417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17524417 |
| http://purl.uniprot.org/uniprot/#_Q6XXM1-mappedCitation-17524417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17524417 |
| http://purl.uniprot.org/uniprot/A5HUM4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17524417 |
| http://purl.uniprot.org/uniprot/Q6XXM1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17524417 |