| http://purl.uniprot.org/citations/17524503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17524503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17524503 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Catenin binds to the cytoplasmic region of the type 1 membrane glycoprotein MUC1. In the current study, we utilized HEK293T cells expressing the full-length MUC1 protein, or a CD8/MUC1 fusion protein containing only the MUC1 cytoplasmic tail, to investigate the effects of beta-catenin binding to MUC1 on downstream beta-catenin-dependent events. Compared with HEK293T cells transfected with empty vector or CD8 alone, expression of the MUC1 cytoplasmic tail inhibited beta-catenin binding to E-cadherin, decreased translocation of beta-catenin into the nucleus, reduced activation of the LEF-1 transcription factor, and blocked expression of the cyclin D1 and c-Myc proteins. Furthermore, expression of MUC1 was associated with decreased cell proliferation, either in the context of the transfected HEK293T cells, or when comparing wild type (Muc1(+/+)) vs. knockout (Muc1(-/-)) mouse primary tracheal epithelial cells. We conclude that MUC1 inhibits cell proliferation through a beta-catenin/LEF-1/cyclin D1/c-Myc pathway."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2007.04.009"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2007.04.009"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Kim K.C."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Kim K.C."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Goldblum S.E."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Goldblum S.E."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Kiser T."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Kiser T."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Lillehoj E.P."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/author | "Lillehoj E.P."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/pages | "1028-1038"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/pages | "1028-1038"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/title | "MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/title | "MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/volume | "1773"xsd:string |
| http://purl.uniprot.org/citations/17524503 | http://purl.uniprot.org/core/volume | "1773"xsd:string |