| http://purl.uniprot.org/citations/17525153 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17525153 | http://www.w3.org/2000/01/rdf-schema#comment | "Indirect evidence suggests that the Müller/glial cell water channel aquaporin-4 (AQP4) modulates K(+) channel function of the closely associated Kir4.1 protein. We used patch clamp to compare Kir4.1 K(+) channel function in freshly isolated Müller cells from retinas of wild-type (+/+) and AQP4 knock-out (-/-) mice. Immunocytochemistry showed a comparable Kir4.1 protein expression pattern in Müller cells from +/+ and -/-retinas, with greatest expression at their end feet. Osmotic water permeability was >4-fold reduced in -/-than in +/+ Müller cells. Resting membrane potential did not differ significantly in +/+ versus -/- Müller cells (-64 +/- 1 versus -64 +/-1 mV, S.E., n = 24). Whole-cell K(+) currents recorded with a micropipette inserted into the cell soma were Ba(2+)-sensitive and showed no significant differences in magnitude in +/+ versus -/- Müller cells (1.3 +/-0.1 versus 1.2 +/-0.1 nA at -160 mV) or in inwardly rectifying current-voltage relationships. Spatially resolved K(+) currents generated by pulsed K(+) injections along Müller cell bodies were also comparable in +/+ versus -/-Müller cells. Single-channel cell-attached patch clamp showed comparable unitary conductance, current-voltage data, and open probability in +/+ versus -/-Müller cells. Thus, contrary to the generally accepted view, our results provide direct evidence against functionally significant AQP4 modulation of Müller cell Kir4.1 K(+) channel function."xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m703236200"xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/author | "Verkman A.S."xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/author | "Ruiz-Ederra J."xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/pages | "21866-21872"xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/title | "Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Muller cells."xsd:string |
| http://purl.uniprot.org/citations/17525153 | http://purl.uniprot.org/core/volume | "282"xsd:string |
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