| http://purl.uniprot.org/citations/17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/17525156 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone methylation is a reversible modification regulated by the antagonistic functions of residue-specific histone methyltransferases and demethylases. Although methylation of histone H3 at lysines 4 and 36 is linked to transcription, the roles of histone demethylases in transcription regulation are not understood. Here we show that overexpression of either Jhd1 or Rph1, two JmjC-domain proteins, bypasses the requirement for the positive elongation factor gene BUR1. Biochemical analysis and chromatin immunoprecipitation experiments indicate that Rph1 functions as a specific demethylase for H3 K36me3 and K36me2, directly regulating Lys(36) methylation in transcribed regions. Both Jhd1 and Rph1 are required for normal levels of RNA polymerase II cross-linking to genes. Taken together, these findings indicate that a general function of histone demethylases for H3 Lys(36) is to promote transcription elongation by antagonizing repressive Lys(36) methylation by Set2."xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m703034200"xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17525156 |
| http://purl.uniprot.org/citations/17525156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17525156 |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/author | "Buratowski S."xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/pages | "20827-20835"xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/title | "Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation."xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17525156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17525156 |
| http://purl.uniprot.org/citations/17525156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17525156 |
| http://purl.uniprot.org/uniprot/#_A0A8H8ULR6-mappedCitation-17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UM32-mappedCitation-17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/#_P23293-mappedCitation-17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/#_P39956-mappedCitation-17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/#_P40034-mappedCitation-17525156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/P40034#attribution-90B366BCDF938A57F34B15B9981AE5E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/P39956#attribution-51E754B26879DC13C50EB971705D8311 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/P39956#attribution-90B366BCDF938A57F34B15B9981AE5E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/enzyme/1.14.11.69 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17525156 |
| http://purl.uniprot.org/uniprot/A0A8H8ULR6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17525156 |