| http://purl.uniprot.org/citations/17525342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17525342 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17525342 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA damage response. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. RAP80 contains a tandem ubiquitin-interacting motif domain, which is required for its binding with ubiquitin in vitro and its damage-induced foci formation in vivo. Moreover, RAP80 specifically recruits BRCA1 to DNA damage sites and functions with BRCA1 in G2/M checkpoint control. Together, these results suggest the existence of a ubiquitination-dependent signaling pathway involved in the DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1139621"xsd:string |
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| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/pages | "1202-1205"xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/pages | "1202-1205"xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/title | "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/title | "Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/volume | "316"xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://purl.uniprot.org/core/volume | "316"xsd:string |
| http://purl.uniprot.org/citations/17525342 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17525342 |
| http://purl.uniprot.org/citations/17525342 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17525342 |
| http://purl.uniprot.org/citations/17525342 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17525342 |
| http://purl.uniprot.org/citations/17525342 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17525342 |