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| http://purl.uniprot.org/citations/17525357 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoclasts play a vital role in orthodontic tooth movement. Transactivation of nuclear factor kappaB (NFkappaB) by phosphorylation of the p65 component of NFkappaB at amino acid 536 (p65*(536)) plays a role in osteoclast differentiation stimulated by receptor activator of nuclear factor kappaB-ligand (RANK-L). We hypothesized that this transactivation pathway might be involved in the responses of alveolar bone cells during orthodontic tooth movement. We detected sharp increases in the levels of p65*(536) 3 and 12 hrs after the application of orthodontic stimuli in rats. In cell culture, osteoclast-like cells displayed no changes in p65*(536) in response to RANK-L, but levels rapidly increased after the cells were mechanically scraped. We conclude that p65*(536) is produced rapidly in response to orthodontic stimuli and mechanical insults, and may be important in bone remodeling associated with orthodontic tooth movement."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.org/dc/terms/identifier | "doi:10.1177/154405910708600613"xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/author | "Johnson K.L."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/author | "Zuo J."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/author | "Cooper A."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/author | "Holliday L.S."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/author | "Archer L.A."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/author | "Dolce C."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/name | "J Dent Res"xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/pages | "556-559"xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/title | "Nuclear factor kappaB p65 phosphorylation in orthodontic tooth movement."xsd:string |
| http://purl.uniprot.org/citations/17525357 | http://purl.uniprot.org/core/volume | "86"xsd:string |
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