| http://purl.uniprot.org/citations/17526848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17526848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17526848 | http://www.w3.org/2000/01/rdf-schema#comment | "The FimA fimbriae of Porphyromonas gingivalis, the causative agent of periodontitis, have been implicated in various aspects of pathogenicity, such as colonization, adhesion and aggregation. In this study, the four open reading frames (ORF1, ORF2, ORF3 and ORF4) downstream of the fimbrilin gene (fimA) in strain ATCC 33277 were examined. ORF2, ORF3 and ORF4 were demonstrated to encode minor components of the fimbriae and were therefore renamed fimC, fimD and fimE, respectively. Immunoblotting analyses revealed that inactivation of either fimC or fimD by an ermF-ermAM insertion, but not inactivation of ORF1, was accompanied by concomitant loss of the products from the downstream genes, raising the possibility that fimC, fimD and fimE constitute a transcription unit. The fimE mutant produced FimC and FimD, but fimbriae purified from it contained neither protein, suggesting that FimE is required for the assembly of FimC and FimD onto the fimbrilin (FimA) fibre. The fimC, fimD and fimE mutants lost autoaggregation abilities. Fimbriae purified from these three mutants showed attenuated binding activities to glyceraldehyde-3-phosphate dehydrogenase of Streptococcus oralis and to two extracellular matrix proteins, fibronectin and type I collagen. These results suggest that FimE, as well as FimC and FimD, play critical roles in the adhesive activities of the mature FimA fimbriae in P. gingivalis."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.org/dc/terms/identifier | "doi:10.1099/mic.0.2006/005561-0"xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.org/dc/terms/identifier | "doi:10.1099/mic.0.2006/005561-0"xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Yoshimura F."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Yoshimura F."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Kawagishi I."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Kawagishi I."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Nagata H."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Nagata H."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Nishiyama S."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Nishiyama S."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Shizukuishi S."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/author | "Shizukuishi S."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/name | "Microbiology"xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/name | "Microbiology"xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/pages | "1916-1925"xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/pages | "1916-1925"xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/title | "Involvement of minor components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions."xsd:string |
| http://purl.uniprot.org/citations/17526848 | http://purl.uniprot.org/core/title | "Involvement of minor components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions."xsd:string |