| http://purl.uniprot.org/citations/17529993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17529993 | http://www.w3.org/2000/01/rdf-schema#comment | "The histone chaperone SET is required for transcription of chromatin templates by RNA polymerase Pol II (Pol II) in vitro. Here we uncover a positive role for SET in dislodging DEK and PARP1, which restrict access to chromatin in the absence of SET and the PARP1 substrate NAD(+). SET binds chromatin, dissociating DEK and PARP1 to allow transcription in the absence of NAD(+). In the absence of SET, depletion of DEK restores chromatin accessibility to endonuclease but does not permit Mediator recruitment or transcription. In the presence of NAD(+), PARP1 poly(ADP-ribosyl)ates and evicts DEK (and itself) from chromatin to permit Mediator loading and transcription independent of SET. An artificial DEK variant resistant to SET and PARP1 represses transcription, indicating a requirement for DEK removal. Therefore, SET, DEK and PARP1 constitute a network governing access to chromatin by the transcription machinery."xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb1248"xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/author | "Fisher R.P."xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/author | "Gamble M.J."xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/pages | "548-555"xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/title | "SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery."xsd:string |
| http://purl.uniprot.org/citations/17529993 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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