| http://purl.uniprot.org/citations/17531812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17531812 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17531812 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian Retinoblastoma (RB) family including pRB, p107, and p130 represses E2F target genes through mechanisms that are not fully understood. In D. melanogaster, RB-dependent repression is mediated in part by the multisubunit protein complex Drosophila RBF, E2F, and Myb (dREAM) that contains homologs of the C. elegans synthetic multivulva class B (synMuvB) gene products. Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a p130 complex termed DP, RB-like, E2F, and MuvB (DREAM) that contains mammalian homologs of synMuvB proteins LIN-9, LIN-37, LIN-52, LIN-54, and LIN-53/RBBP4. DREAM bound to more than 800 human promoters in G0 and was required for repression of E2F target genes. In S phase, MuvB proteins dissociated from p130 and formed a distinct submodule that bound MYB. This work reveals an evolutionarily conserved multisubunit protein complex that contains p130 and E2F4, but not pRB, and mediates the repression of cell cycle-dependent genes in quiescence."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.04.015"xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.04.015"xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Swanson S.K."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Swanson S.K."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Litovchick L."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Litovchick L."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Velmurugan S."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Velmurugan S."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Liu X.S."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Liu X.S."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Sadasivam S."xsd:string |
| http://purl.uniprot.org/citations/17531812 | http://purl.uniprot.org/core/author | "Sadasivam S."xsd:string |