| http://purl.uniprot.org/citations/17532053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17532053 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-21 has a pro-apoptotic effect on freshly isolated B cells stimulated with LPS, and also induces Bcl6 expression in the activated B cells. However, a role for Bcl6 in the activated B cells is not known. When naive B cells from Bcl6-deficient mice were stimulated with LPS plus IL-21, those B cells died by apoptosis as wild-type B cells. Co-stimulation of those B cells with IL-4 partially rescued the wild-type B cells but not the Bcl6-deficient B cells from the IL-21-induced apoptosis. Bcl-2 was not up-regulated in both B cells stimulated with LPS plus IL-21 and IL-4. Bcl-X(L) and Bax were up-regulated in both B cells stimulated with LPS plus IL-4, and the co-stimulation with IL-21 did not modulate these up-regulations in wild-type B cells. However, the co-stimulation clearly suppressed the Bcl-X(L) up-regulation but not the Bax up-regulation in Bcl6-deficient B cells. Thus, Bcl6 is required for maintaining the Bcl-X(L) up-regulation in B cells stimulated with LPS plus IL-21 and IL-4, and the up-regulation may partially rescue the B cells from apoptosis induced by IL-21."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imlet.2007.04.009"xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Sakamoto A."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Tokuhisa T."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Hatano M."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Arima M."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Tsuruoka N."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Arguni E."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/author | "Kitayama D."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/pages | "145-151"xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/title | "Bcl6 is required for the IL-4-mediated rescue of the B cells from apoptosis induced by IL-21."xsd:string |
| http://purl.uniprot.org/citations/17532053 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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