http://purl.uniprot.org/citations/17532368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17532368 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionWe have previously demonstrated platelet hyperreactivity in cystic fibrosis (CF) patients. Carriers of one CF mutation (heterozygotes) have been shown to have abnormalities related to the presence of only one-half the normal amount of CF transmembrane conductance regulator protein. Platelet hyperreactivity in CF heterozygotes would be an important cardiovascular risk factor, since approximately 1 in 25 Caucasians is a CF carrier.Materials and methodsWe used highly sensitive assays of platelet activation to assess the difference between 16 CF heterozygotes and 16 age- and sex-matched healthy controls without CF mutations.ResultsWe found no difference in platelet activation between CF heterozygotes and controls.ConclusionsThe 50% reduction in the CF transmembrane conductance regulator protein in heterozygotes is insufficient to cause platelet activation."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.thromres.2007.04.004"xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Barnard M.R."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Linden M.D."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Michelson A.D."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Fox M.L."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "O'Sullivan B.P."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Frelinger A.L."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/author | "Tarnow I."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/name | "Thromb Res"xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/pages | "159-162"xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/title | "Cystic fibrosis heterozygotes do not have increased platelet activation."xsd:string |
http://purl.uniprot.org/citations/17532368 | http://purl.uniprot.org/core/volume | "121"xsd:string |
http://purl.uniprot.org/citations/17532368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17532368 |
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