| http://purl.uniprot.org/citations/17532644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17532644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17532644 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytoskeleton and cytoskeletal motors play a fundamental role in neurotransmitter receptor trafficking, but proteins that link GABA(B) receptors (GABA(B)Rs) to the cytoskeleton have not been described. We recently identified Marlin-1, a protein that interacts with GABA(B)R1. Here, we explore the association of GABA(B)Rs and Marlin-1 to the cytoskeleton using a combination of biochemistry, microscopy and live cell imaging. Our results indicate that Marlin-1 is associated to microtubules and the molecular motor kinesin-I. We demonstrate that a fraction of Marlin-1 is mobile in dendrites of cultured hippocampal neurons and that mobility is microtubule-dependent. We also show that GABA(B)Rs interact robustly with kinesin-I and that intracellular membranes containing GABA(B)Rs are sensitive to treatments that disrupt a protein complex containing Marlin-1, kinesin-I and tubulin. Finally, we report that a kinesin-I mutant severely impairs receptor transport. We conclude that Marlin-1 and kinesin-1 link GABA(B)Rs to the tubulin cytoskeleton in neurons."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2007.04.008"xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2007.04.008"xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Couve A."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Couve A."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Haertel S."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Haertel S."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Koenig-Robert R."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Koenig-Robert R."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Ramirez O.A."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Ramirez O.A."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Sandoval L."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Sandoval L."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Vidal R.L."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/author | "Vidal R.L."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/pages | "501-512"xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/pages | "501-512"xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/title | "Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport."xsd:string |
| http://purl.uniprot.org/citations/17532644 | http://purl.uniprot.org/core/title | "Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport."xsd:string |