| http://purl.uniprot.org/citations/17534701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17534701 | http://www.w3.org/2000/01/rdf-schema#comment | "The PS-R gene product was originally described as a cell surface receptor that interacts with externalized phosphatidylserine (PS) on apoptotic cells, but more recent studies have shown that it plays a critical role in organ development and terminal differentiation of many cell types during embryogenesis. Despite these important developmental functions, the biochemical and molecular properties of PS-R are poorly understood. Here we have used several approaches to show that PS-R undergoes processive post-translational protein cross-linking to form covalent multimers within the nuclear compartment. Although PS-R has a potential Glu-Glu (QQ) duet that is often targeted by transglutaminase TG-2, the oligomerization of PS-R was not effected by QQ-->AA mutation, or when PS-R gene product was expressed in TG-2 (-/-) fibroblasts. Pulse-chase experiments with (35) S-methionine indicates that the PS-R undergoes an initial proteolytic cleavage, followed by progressive multimerization of the monomeric subunits over time. In summary, we report here that PS-R is modified by an unusual post-translational modification, and we speculate that homomultimer of PS-R might be playing an important function as a scaffolding protein in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-007-9492-8"xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/author | "Birge R.B."xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/author | "Tibrewal N."xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/pages | "119-125"xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/title | "Characterization of the biochemical and biophysical properties of the phosphatidylserine receptor (PS-R) gene product."xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/17534701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17534701 |
| http://purl.uniprot.org/citations/17534701 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17534701 |
| http://purl.uniprot.org/uniprot/Q6NYC1#attribution-245A128F694EF321887258C52AFA2E00 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/#_A0A0S2PZM4-mappedCitation-17534701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/#_B2WTI3-mappedCitation-17534701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/#_B2WTI4-mappedCitation-17534701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/#_Q6NYC1-mappedCitation-17534701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/B2WTI4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/Q6NYC1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/A0A0S2PZM4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17534701 |
| http://purl.uniprot.org/uniprot/B2WTI3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17534701 |