| http://purl.uniprot.org/citations/17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17535249 | http://www.w3.org/2000/01/rdf-schema#comment | "The SWI2/SNF2 family ATPase, p400/mDomino, is a core subunit of a large chromatin-remodeling complex, and is currently suggested to play a unique function in histone variant exchange, a process by which chromatin structure is altered. Here, we investigated the role of p400/mDomino in mammalian development by generating mutant mice with a targeted deletion of the N-terminal domain of p400/mDomino (referred to as mDom(DeltaN/DeltaN)). The mDom(DeltaN/DeltaN) mice died on embryonic day 11.5 (E11.5), and displayed an anemic appearance and slight deformity of the neural tube. DNA microarray and quantitative RT-PCR analyses revealed that all of the embryonic globin genes and a globin chaperone gene were poorly expressed in the mDom(DeltaN/DeltaN) embryo and yolk sac on E8.5, indicating that primitive erythropoiesis was impaired. A hematopoietic colony assay indicated that the hematopoietic activity of the yolk sac was significantly blocked in the mutant mice. We also found that the expression of a limited set of Hox genes, including Hoxa7, Hoxa9 and Hoxb9, was drastically enhanced in the mDom(DeltaN/DeltaN) yolk sacs. These results suggest that p400/mDomino plays a critical role in embryonic hematopoiesis by regulating the expression of developmentally essential genes such as those in the Hox gene cluster."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2007.01080.x"xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Higashi Y."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Ogawa H."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Fukunaga R."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Nagata S."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Fukuyama H."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/author | "Watanabe-Fukunaga R."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/pages | "581-592"xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/title | "Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/17535249 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17535249 |
| http://purl.uniprot.org/citations/17535249 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J193-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A087WR88-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWF9-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |
| http://purl.uniprot.org/uniprot/#_D3Z207-mappedCitation-17535249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17535249 |