| http://purl.uniprot.org/citations/17537836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17537836 | http://www.w3.org/2000/01/rdf-schema#comment | "5-HT2 receptor activity in the hypoglossal nucleus and hypercapnia is associated with airway dilation. 5-HT neurons in the medullary raphe and hypercapnia are responsible for tidal volume change. In this study, the effects of 5-HT2 receptors in the dorsomedial medulla oblongata (DMM), which receives projections from the medullary raphe, and hypercapnia on airway resistance and respiratory variables were studied in mice while monitoring 5-HT release in the DMM. A microdialysis probe was inserted into the DMM of anesthetized adult mice. Each mouse was placed in a double-chamber plethysmograph. After recovery from anesthesia, the mice were exposed to stepwise increases in CO(2) inhalation (5%, 7%, and 9% CO(2) in O(2)) at 8-min intervals with a selective serotonin reuptake inhibitor, fluoxetine, or fluoxetine plus a 5-HT2 receptor antagonist, LY-53857 in the DMM. In response to fluoxetine plus LY-53857 coperfusion, specific airway resistance was increased, and tidal volume and minute ventilation were decreased. CO(2) inhalation with fluoxetine plus LY-53857 coperfusion in the DMM largely decreased airway resistance and additively increased minute ventilation. Thus, 5-HT2 receptor activity in the DMM increases basal levels of airway dilation and ventilatory volume, dependent on central inspiratory activity and the volume threshold of the inspiratory off-switch mechanism. Hypercapnia with low 5-HT2 receptor activity in the DMM largely recovers airway dilation and additively increases ventilatory volume. Interaction between 5-HT2 receptor activity in the DMM and CO(2) drive may elicit a cycle of hyperventilation with airway dilation and hypoventilation with airway narrowing."xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00829.2006"xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/author | "Homma I."xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/author | "Kanamaru M."xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/name | "Am J Physiol Regul Integr Comp Physiol"xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/pages | "R854-60"xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/title | "Compensatory airway dilation and additive ventilatory augmentation mediated by dorsomedial medullary 5-hydroxytryptamine 2 receptor activity and hypercapnia."xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/17537836 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17537836 |
| http://purl.uniprot.org/citations/17537836 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17537836 |
| http://purl.uniprot.org/uniprot/#_P35363-mappedCitation-17537836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17537836 |
| http://purl.uniprot.org/uniprot/#_Q543D4-mappedCitation-17537836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17537836 |
| http://purl.uniprot.org/uniprot/P35363 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17537836 |
| http://purl.uniprot.org/uniprot/Q543D4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17537836 |