| http://purl.uniprot.org/citations/17538882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17538882 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus (HIV)-specific CD4(+) T cell cytokine secretion is characteristically weak during HIV infection, in part because HIV-specific CD4(+) T cells undergo massive apoptotic deletion. Glucocorticoid-induced tumor necrosis factor (TNF) receptor family-related (GITR) protein triggering enhances murine antigen-specific T cell cytokine secretion by protecting T cells from apoptosis. Therefore, we investigated the impact of GITR triggering on HIV-specific CD4(+) T cell cytokine secretion and on apoptosis of HIV-specific CD4(+) T cells. In HIV-infected subjects, CD4(+) T cell surface expression of GITR was greater than that in uninfected control subjects, and phytohemagglutinin induction of additional GITR expression was impaired. However, antibody triggering of GITR significantly increased HIV-specific CD4(+) T cell expression of TNF- alpha and interferon (IFN)-gamma . The percentage increase in HIV-specific CD4(+) T cell expression of TNF-alpha correlated directly with the absolute peripheral CD4(+) T cell count. Furthermore, GITR triggering reduced the expression of intracellular activated caspase-3 in HIV-specific CD4(+) T cells. Taken together, these data suggest that, despite abnormal GITR expression during HIV infection, GITR triggering enhances HIV-specific CD4(+) T cell cytokine expression and protects HIV-specific CD4(+) T cells from apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.org/dc/terms/identifier | "doi:10.1086/518613"xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/author | "Loisel S.D."xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/author | "Lahey T.P."xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/author | "Wieland-Alter W."xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/pages | "43-49"xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/title | "Glucocorticoid-induced tumor necrosis factor receptor family-related protein triggering enhances HIV-specific CD4+ T cell cytokine secretion and protects HIV-specific CD4+ T cells from apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://purl.uniprot.org/core/volume | "196"xsd:string |
| http://purl.uniprot.org/citations/17538882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17538882 |
| http://purl.uniprot.org/citations/17538882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17538882 |
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| http://purl.uniprot.org/uniprot/#_Q9Y5U5-mappedCitation-17538882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17538882 |
| http://purl.uniprot.org/uniprot/A0A0R7FDM1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17538882 |
| http://purl.uniprot.org/uniprot/Q9Y5U5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17538882 |
| http://purl.uniprot.org/uniprot/A8WFP4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17538882 |