| http://purl.uniprot.org/citations/17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17540176 | http://www.w3.org/2000/01/rdf-schema#comment | "The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme family that regulates numerous signaling pathways. Biallelic mutations of the structural PP2A Abeta subunit occur in several types of human tumors; however, the functional consequences of these cancer-associated PP2A Abeta mutations in cell transformation remain undefined. Here we show that suppression of PP2A Abeta expression permits immortalized human cells to achieve a tumorigenic state. Cancer-associated Abeta mutants fail to reverse tumorigenic phenotype induced by PP2A Abeta suppression, indicating that these mutants function as null alleles. Wild-type PP2A Abeta but not cancer-derived Abeta mutants form a complex with the small GTPase RalA. PP2A Abeta-containing complexes dephosphorylate RalA at Ser183 and Ser194, inactivating RalA and abolishing its transforming function. These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.03.047"xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Hahn W.C."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Arroyo J.D."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Corral L."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Sablina A.A."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Bulmer S.E."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/author | "Hector M."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/pages | "969-982"xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/title | "The tumor suppressor PP2A Abeta regulates the RalA GTPase."xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/17540176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17540176 |
| http://purl.uniprot.org/citations/17540176 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17540176 |
| http://purl.uniprot.org/uniprot/#_P11233-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |
| http://purl.uniprot.org/uniprot/#_Q15628-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |
| http://purl.uniprot.org/uniprot/#_B7Z1G3-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |
| http://purl.uniprot.org/uniprot/#_A8K8B0-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |
| http://purl.uniprot.org/uniprot/#_P03081-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |
| http://purl.uniprot.org/uniprot/#_P62834-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |
| http://purl.uniprot.org/uniprot/#_P25205-mappedCitation-17540176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540176 |