| http://purl.uniprot.org/citations/17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17540767 | http://www.w3.org/2000/01/rdf-schema#comment | "During viral infection, cells initiate antiviral responses to contain replication and inhibit virus spread. One protective mechanism involves activation of transcription factors interferon regulatory factor-3 (IRF-3) and NF-kappaB, resulting in secretion of the antiviral cytokine, interferon-beta. Another is induction of apoptosis, killing the host cell before virus disseminates. Mammalian reovirus induces both interferon-beta and apoptosis, raising the possibility that both pathways are initiated by a common cellular sensor. We show here that reovirus activates IRF-3 with kinetics that parallel the activation of NF-kappaB, a known mediator of reovirus-induced apoptosis. Activation of IRF-3 requires functional retinoic acid inducible gene-I and interferon-beta promoter stimulator-1, but these intracellular sensors are dispensable for activation of NF-kappaB. Interferon-beta promoter stimulator-1 and IRF-3 are required for efficient apoptosis following reovirus infection, suggesting a common mechanism of antiviral cytokine induction and activation of the cell death response."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m702112200"xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Hiscott J."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Dermody T.S."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Danthi P."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Holm G.H."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Sherry B."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Leveille S."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Tumilasci V."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/author | "Zurney J."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/pages | "21953-21961"xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/title | "Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3."xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17540767 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17540767 |
| http://purl.uniprot.org/citations/17540767 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17540767 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |
| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |
| http://purl.uniprot.org/uniprot/#_Q14653-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |
| http://purl.uniprot.org/uniprot/#_M0QYT9-mappedCitation-17540767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17540767 |