| http://purl.uniprot.org/citations/17543336 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17543336 | http://www.w3.org/2000/01/rdf-schema#comment | "p21-Activated kinases (PAKs) are serine/threonine kinases involved in multiple cellular functions including cytoskeleton regulation, proliferation and apoptosis. We performed a screen for proteins interacting with PAK-2, a ubiquitously expressed kinase involved in apoptotic signaling. Among the PAK-2 interacting proteins were different members of the Abl-binding protein family. Abl-binding proteins bound to a proline-rich region of PAK-2 located in the regulatory N terminus. Moreover, active PAK-2 phosphorylated Abl-binding proteins in vitro. Interestingly, we show that PAK-2 also interacted with c-Abl but via a different domain than with the Abl-binding proteins. PAK-2 and Abi-1 co-localized in the cytoplasm and to membrane dorsal ruffles induced by PDGF treatment. Expression of mutant PAK-2 deficient in binding to Abl-binding proteins or silencing of PAK-2 expression prevented the formation of membrane dorsal ruffles in response to PDGF. Our findings define a new class of PAK-interacting proteins, which play an important role in actin cytoskeletal reorganization."xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2007.04.080"xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/author | "Rudel T."xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/author | "Machuy N."xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/author | "Campa F."xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/author | "Thieck O."xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/pages | "620-632"xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/title | "c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles."xsd:string |
| http://purl.uniprot.org/citations/17543336 | http://purl.uniprot.org/core/volume | "370"xsd:string |
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