| http://purl.uniprot.org/citations/17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17544403 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular responses to DNA damage after hypoxia and reoxygenation (H/R) were examined in human lymphocytes. Cultured lymphocytes exposed to H/R showed a lower cytokinesis block proliferation index and a higher frequency of micronuclei in comparison to control cells. Western blots showed that H/R exposure induced p53 expression; however, p21 and Bax expression did not increase, indicating that H/R did not affect p53 transactivational activity. Phosphorylation of p53 (Ser15), Chk1 (Ser345), and Chk2 (Thr68) was also observed, suggesting that H/R activates p53 through checkpoint signals. In addition, H/R exposure caused the phosphorylation and negative regulation of Cdc2 and Cdc25C, proteins that are involved in cell-cycle arrest at the G2/M checkpoint. The S-phase checkpoint, regulated by the ATM-p95/NBS1-SMC1 pathway, was also triggered in H/R-exposed lymphocytes. These results demonstrate that H/R exposure triggers checkpoint signaling and induces cell-cycle arrest in cultured human lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.05.053"xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/author | "Choi J.Y."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/author | "Kim B.M."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/author | "Chung H.W."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/author | "Woo H.D."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/pages | "3005-3012"xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/title | "Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://purl.uniprot.org/core/volume | "581"xsd:string |
| http://purl.uniprot.org/citations/17544403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17544403 |
| http://purl.uniprot.org/citations/17544403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A346XLN8-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A346XLS8-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |
| http://purl.uniprot.org/uniprot/#_A0A346XLT4-mappedCitation-17544403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17544403 |