| http://purl.uniprot.org/citations/17545244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17545244 | http://www.w3.org/2000/01/rdf-schema#comment | "I(Ks) channels contain four pore-forming KCNQ1 subunits and two accessory MinK subunits. MinK influences surface expression, voltage-dependence of gating, conduction, and pharmacology to yield the attributes characteristic of native channels in heart. The structure and location of the MinK transmembrane domain (TMD) remains a matter of scrutiny. As perturbation of gating analysis has correctly inferred the peripheral location and alpha-helical nature of TMDs in pore-forming subunits, the method is applied here to human MinK. Tryptophan and Asparagine substitution at 23 consecutive sites yields perturbation with alpha-helical periodicity (residues 44-56) followed by an alternating impact pattern (residues 56-63). Arginine substitution across the span suggests that as few as eight sites are occluded from aqueous solution (residues 50-57). We favor a TMD model that is alpha-helical with the external portion of the span at a lipid-protein boundary and the inner portion within the channel corpus in complex interactions."xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.org/dc/terms/identifier | "doi:10.1529/biophysj.107.109702"xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/author | "Goldstein S.A."xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/name | "Biophys J"xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/pages | "2332-2340"xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/title | "Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus."xsd:string |
| http://purl.uniprot.org/citations/17545244 | http://purl.uniprot.org/core/volume | "93"xsd:string |
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