| http://purl.uniprot.org/citations/17545585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17545585 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer cells often gain advantage by reducing the tumor-suppressive activity of transforming growth factor-beta (TGF-beta) together with stimulation of its oncogenic activity as in Ras-transformed cells; however, molecular mechanisms remain largely unknown. TGF-beta activates both its type I receptor (TbetaRI) and c-Jun NH2-terminal kinase (JNK), which phosphorylate Smad2 and Smad3 at the COOH-terminal (pSmad2/3C) and linker regions (pSmad2/3L). Here, we report that Ras transformation suppresses TbetaRI-mediated pSmad3C signaling, which involves growth inhibition by down-regulating c-Myc. Instead, hyperactive Ras constitutively stimulates JNK-mediated pSmad2/3L signaling, which fosters tumor invasion by up-regulating plasminogen activator inhibitor-1 and matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-9. Conversely, selective blockade of linker phosphorylation by a mutant Smad3 lacking JNK-dependent phosphorylation sites results in preserved tumor-suppressive function via pSmad3C in Ras-transformed cells while eliminating pSmad2/3L-mediated invasive capacity. Thus, specific inhibition of the JNK/pSmad2/3L pathway should suppress cancer progression by shifting Smad-dependent signaling from oncogenesis to tumor suppression."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-4629"xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Matsui H."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Mori S."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Seki T."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Murata M."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Matsuzaki K."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Okazaki K."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Fujisawa J."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/author | "Sekimoto G."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/pages | "5090-5096"xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/title | "Reversible Smad-dependent signaling between tumor suppression and oncogenesis."xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17545585 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17545585 |
| http://purl.uniprot.org/citations/17545585 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17545585 |
| http://purl.uniprot.org/uniprot/P84025#attribution-708BDF437726039DF2BC41C38784E4E2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17545585 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K0P2-mappedCitation-17545585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17545585 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZQC4-mappedCitation-17545585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17545585 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZS20-mappedCitation-17545585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17545585 |
| http://purl.uniprot.org/uniprot/#_A6J5A4-mappedCitation-17545585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17545585 |
| http://purl.uniprot.org/uniprot/#_A6KMS7-mappedCitation-17545585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17545585 |