| http://purl.uniprot.org/citations/17546694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17546694 | http://www.w3.org/2000/01/rdf-schema#comment | "Recovery from Hepatitis C virus (HCV) infection is considered infrequent (<20%) in western populations but reaches 50% in West Africa where genotype 2 infection is predominant. To investigate the role of cellular immune responses and host genetics in this phenomenon, samples from 104 Ghanaian blood donors reactive with anti-HCV assays were collected between 2000 and 2005. HCV antibody was confirmed by Western blot using genotype 2 recombinant core, E2 and NS3 proteins. Viral load and genotype were determined. Samples were stratified into 37 chronic, 35 recovered infections and 32 false positive. Eighty-one percentage of subjects with chronic infection (RNA positive) carried genotype 2 HCV. Cellular immune response was investigated in 35 frozen peripheral blood mononuclear cell (PBMC) samples suitable for interferon-gamma ELISPOT assay. Twelve out of 24 confirmed recovered, 1 out of 5 chronically infected and none of the 6 false-positive controls reacted to recombinant proteins. HLA-A, -B and -DR types were determined by DNA methodology. HLA-B*57 was significantly more frequent in the group which had recovered from HCV infection compared with chronically infected subjects (P = 0.0053, OR = 8.02). In conclusion, it is hypothesized that the dominance of genotype 2 HCV strains may be an important factor explaining the high rate of recovery from HCV infections in Ghana via an efficient contribution of HLA-B*57 which is relatively frequent in the population."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.org/dc/terms/identifier | "doi:10.1002/jmv.20848"xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Brown C.J."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Brown J."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Allain J.P."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Owusu-Ofori S."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Klenerman P."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Navarrete C."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Sarkodie F."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/author | "Chuang W.C."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/name | "J Med Virol"xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/pages | "724-733"xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/title | "Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population."xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/17546694 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17546694 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-17546694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17546694 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-17546694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17546694 |