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| http://purl.uniprot.org/citations/17549732 | http://www.w3.org/2000/01/rdf-schema#comment | "We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells. We find that while T cell help for all antibody isotypes (including IgG2c) is impaired in ICOS knockout (ICOS-KO) mice, the IFN-gamma response is little affected, indicating a defect in helper function that is unrelated to cytokine production. In addition, the ICOS-negative T cells do not accumulate in B cell follicles. Secondary (memory), but not primary, clonal proliferation of antigen-specific B cells is impaired in ICOS-KO mice, as is the generation of secondary antibody-secreting cells. Analysis of endogenous CD4 memory cells in ICOS-KO mice, using MHC class II tetramers, reveals normal primary clonal expansion, formation of memory clones and long-term (10 wk) survival of memory cells, but defective expansion upon reactivation in vivo. The data point to a role of ICOS in supporting secondary, memory and effector T cell responses, possibly by influencing cell survival. The data also highlight differences in ICOS dependency of endogenous T cell proliferation in vivo compared to that of adoptively transferred TCR-transgenic T cells."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636661"xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Meek S."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "MacDonald A."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Mahajan S."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Gray D."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "MacLeod M."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Fillatreau S."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Cervera A."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/author | "Perona-Wright G."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/pages | "1796-1808"xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/title | "The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells."xsd:string |
| http://purl.uniprot.org/citations/17549732 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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