| http://purl.uniprot.org/citations/17550782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17550782 | http://www.w3.org/2000/01/rdf-schema#comment | "S6 kinase (S6K) deletion in metazoans causes small cell size, insulin hypersensitivity, and metabolic adaptations; however, the underlying molecular mechanisms are unclear. Here we show that S6K-deficient skeletal muscle cells have increased AMP and inorganic phosphate levels relative to ATP and phosphocreatine, causing AMP-activated protein kinase (AMPK) upregulation. Energy stress and muscle cell atrophy are specifically triggered by the S6K1 deletion, independent of S6K2 activity. Two known AMPK-dependent functions, mitochondrial biogenesis and fatty acid beta-oxidation, are upregulated in S6K-deficient muscle cells, leading to a sharp depletion of lipid content, while glycogen stores are spared. Strikingly, AMPK inhibition in S6K-deficient cells restores cell growth and sensitivity to nutrient signals. These data indicate that S6K1 controls the energy state of the cell and the AMPK-dependent metabolic program, providing a mechanism for cell mass accumulation under high-calorie diet."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2007.05.006"xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Carling D."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Viollet B."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Benit P."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Rustin P."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Sandri M."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Djouadi F."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Pende M."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Foretz M."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Bastin J."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Ventura-Clapier R."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Sotiropoulos A."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Diolez P."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Thiaudiere E."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Alliouachene S."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Athea Y."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Aguilar V."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Miraux S."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/author | "Sobering A."xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/pages | "476-487"xsd:string |
| http://purl.uniprot.org/citations/17550782 | http://purl.uniprot.org/core/title | "S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase."xsd:string |