| http://purl.uniprot.org/citations/17554680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17554680 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe the localization of three proteins of the minichromosome maintenance (MCM) family, Mcm2, -6 and -7 in mouse ovarian oocytes. We showed that Mcm proteins are stored in two forms: soluble and insoluble. Soluble Mcm2, -6 and -7 were uniformly distributed in the nuclei of ovarian oocytes. Insoluble Mcm2 and Mcm7 (but not Mcm6) were detected in the nuclei of resting, growing and fully-grown transcribing oocytes. In transcriptionally inactive fully-grown oocytes, Mcm2 underwent redistribution and Mcm7 disappeared. A similar effect was observed when transcription in growing oocytes was inhibited with alpha-amanitin. We postulate that in mouse oogenesis, the insoluble Mcm proteins are engaged in processes related to regulation of transcription and/or chromatin organization. In oocytes preparing for meiotic maturation, aggregates of the insoluble form of Mcm2 fragmented, dispersed and ultimately disappeared from the nuclei. Numerous Mcm2-positive deposits were observed in the cytoplasm of maturing oocytes. In the one-cell embryo, insoluble Mcm2 appeared in the G1 nucleus, persisted in the S phase and was undetectable in the G2 nucleus. Such behavior of Mcm2 supports its involvement in chromatin licensing in the first embryonic cell cycle."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.org/dc/terms/identifier | "doi:10.1387/ijdb.062239ls"xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/author | "Borsuk E."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/author | "Kisiel K."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/author | "Czolowska R."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/author | "Swiech L."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/author | "Zientarski M."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/name | "Int J Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/pages | "283-295"xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/title | "Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle."xsd:string |
| http://purl.uniprot.org/citations/17554680 | http://purl.uniprot.org/core/volume | "51"xsd:string |
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