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http://purl.uniprot.org/citations/17557253http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17557253http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To analyze the mutations of BRCA1 in breast cancer patients of Uigur women in Xinjiang.

Methods

By using single strand conformation polymorphism (SSCP) and DNA sequencing, BRCA1 mutations were detected in 70 Uigur women breast cancer cases and 32 cases of benign breast diseases and non-tumor tissue next to carcinoma.

Results

(1) 12 new loci of BRCA1 gene mutation were detected firstly in 70 Uigur women breast cancer patients. (2)The frequency of BRCA1 mutation in 70 Uigur women breast cancer cases was 12.86% (9/70). The frequency of BRCA1 mutation in Uigur women early onset breast cancer was 31.82% (7/22), which was significantly higher than that in late onset group (2/48, 4.16%) (chi(2) =10.295, P<0.01). (3) There were BRCA1 gene polymorphisms in 9 of 70 Uigur women breast cancer patients. The loci of polymorphisms in 8 of 9 cases were 3232A>G. (4)In the research group two cases of bilateral breast cancer were found with BRCA1 gene mutation.

Conclusion

The mutation of BRCA1 gene may be related to Uigur women breast cancer and bilateral breast cancer."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Li F."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Li L."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Wang Z.H."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Shen X.H."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Jiang J.F."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Hu W.H."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Zheng Y.Q."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Fu X.G."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Li H.A."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Mikai R.M."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/author"Pang L.J."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/pages"341-344"xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/title"[Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang]."xsd:string
http://purl.uniprot.org/citations/17557253http://purl.uniprot.org/core/volume"24"xsd:string
http://purl.uniprot.org/citations/17557253http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17557253
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