| http://purl.uniprot.org/citations/17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17557373 | http://www.w3.org/2000/01/rdf-schema#comment | "The B lymphocyte-activating factor belonging to TNF superfamily (BAFF) acts on B lymphocytes through BAFF receptor (BAFF-R), the transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI), and the B cell maturation antigen (BCMA). Another cytokine, a proliferation-inducing ligand (APRIL), only binds to TACI and BCMA. In this study, we sought to determine the effect of Toll-like receptor agonists (TLR-A) on the expression of BAFF/APRIL receptors by murine splenic B lymphocytes. CpG oligodeoxynucleotides (ODN) and LPS strongly up-regulated TACI expression, while BAFF-R was only up-regulated by CpG ODN. CpG ODN pretreatment up-regulated TACI expression on follicular and marginal zone B lymphocytes and increased their responses to BAFF- and APRIL-mediated Ig secretion. TACI seemed to be playing a pivotal role in BAFF- or APRIL-induced Ig secretion because B lymphocytes from TACI-knockout mouse or the blocking of TACI with a neutralizing antibody resulted in total inhibition of IgA and IgG secretion in CpG ODN-pretreated and BAFF- or APRIL-stimulated B cells. Thus, CpG ODN-induced increase in TACI expression is likely to play an important role in Ig secretion following activation of B lymphocytes through TLR9."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636800"xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/author | "Puig M."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/author | "Mostowski H."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/author | "Akkoyunlu M."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/author | "Verthelyi D."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/author | "Kanswal S."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/author | "Katsenelson N."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/pages | "1785-1795"xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/title | "Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion."xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/17557373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17557373 |
| http://purl.uniprot.org/citations/17557373 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17557373 |
| http://purl.uniprot.org/uniprot/#_A5D8Y6-mappedCitation-17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/#_A5D8Y7-mappedCitation-17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/#_B1ATI3-mappedCitation-17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/#_B1ATI4-mappedCitation-17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/#_Q3U2P4-mappedCitation-17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/#_Q9ET35-mappedCitation-17557373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/A5D8Y6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/Q9ET35 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17557373 |
| http://purl.uniprot.org/uniprot/A5D8Y7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17557373 |