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http://purl.uniprot.org/citations/17557568http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Aims

There is mounting evidence that deregulation of apoptosis is involved in the mechanisms of cancer development. Somatic mutations of apoptosis-related genes have been reported in many human cancers. The aim of this study was to explore the possibility that mutation of the BH3 domains of the proapoptotic Bcl-2 genes Bad, Bmf and Bcl-G might be involved in the development of laryngeal cancer.

Methods

We analyzed the BH3 domains of Bad, Bmf and Bcl-G for the detection of somatic mutations in 33 squamous cell carcinomas of the larynx by a polymerase chain reaction-based single-strand conformation polymorphism assay.

Results

There were no somatic mutations of the BH3 domains of Bad, Bmfand BcI-G in the laryngeal squamous cell carcinoma samples.

Conclusions

The data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/17557568http://purl.org/dc/terms/identifier"doi:10.1177/030089160709300214"xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/author"Lee S.H."xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/author"Lee S.H.'"xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/author"Yoo N.J."xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/author"Soung Y.H."xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/author"Jeong E.G."xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/date"2007"xsd:gYear
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http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/pages"195-197"xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/title"Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas."xsd:string
http://purl.uniprot.org/citations/17557568http://purl.uniprot.org/core/volume"93"xsd:string
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