| http://purl.uniprot.org/citations/17562386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17562386 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuregulin (NRG)/ErbB receptor signaling pathways have recently been implicated in the reversal of long-term potentiation at hippocampal glutamatergic synapses. Moreover, polymorphisms in NRG-1 and ErbB-4 genes have been linked to an increased risk for developing schizophrenia. ErbB-4 is highly expressed at glutamatergic synapses where it binds to PSD-95 via its carboxyl terminal T-V-V sequence. Here we investigated the expression, localization and trafficking of ErbB-4 in cultured hippocampal neurons by immunocytochemistry, surface protein biotinylation, and live labeling of native receptors. We show that neuronal ErbB-4 is detected at its highest levels in GABAergic interneurons, as observed in vivo. ErbB-4 immunoreactivity precedes PSD-95 expression, with ErbB-4 cluster initially forming in the absence of, but later associating with, PSD-95-positive puncta. By surface protein biotinylation, the fraction of ErbB-4 receptors on the plasma membrane increases from 30% to 65% between 6 and 16 days in vitro (DIV). Interestingly, 30 min of NRG stimulation triggers measurable ErbB-4 receptor internalization at DIV 16, despite increased colocalization with PSD-95. We also investigated the role of TNFalpha-converting enzyme (TACE)-mediated receptor processing in regulating ErbB-4 surface expression. We found that the cleavage-resistant JM-b isoform accounts for 80% of all ErbB-4 transcripts in cultured hippocampal neurons. Receptor stimulation or treatment with phorbol esters does not induce detectable ErbB-4 processing, indicating that neurons mostly rely on endocytosis of the intact receptor to regulate ErbB-4 surface expression. These results enhance our understanding of the regulation of ErbB-4--mediated signaling at glutamatergic synapses."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainresbull.2007.02.014"xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/author | "Buonanno A."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/author | "Gonzalez C.M."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/author | "Vullhorst D."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/author | "Longart M."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/author | "Chatani-Hinze M."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/name | "Brain Res Bull"xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/pages | "210-219"xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/title | "Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons."xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/17562386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17562386 |
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| http://purl.uniprot.org/uniprot/#_A0A024QY88-mappedCitation-17562386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562386 |
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| http://purl.uniprot.org/uniprot/#_B0FYA8-mappedCitation-17562386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562386 |