| http://purl.uniprot.org/citations/17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17562770 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection with gram-negative monocytotropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased number of Ehrlichia-specific CD4(+) Th1 cells, the expansion of tumor necrosis factor alpha (TNF-alpha)-producing CD8(+) T cells, and the systemic overproduction of interleukin-10 (IL-10) and TNF-alpha. Here, we investigated the role of CD4(+) and CD8(+) T cells in immunity to Ehrlichia and the pathogenesis of fatal ehrlichiosis caused by infection with low- and high-dose (10(3) and 10(5) bacterial genomes/mouse, respectively) ehrlichial inocula. The CD4(+) T-cell-deficient mice showed exacerbated susceptibility to a lethal high- or low-dose infection and harbored higher bacterial numbers than did wild-type (WT) mice. Interestingly, the CD8(+) T-cell-deficient mice were resistant to a low dose but succumbed to a high dose of Ehrlichia. The absence of CD8(+) T cells abrogated TNF-alpha and IL-10 production, reduced tissue injury and bacterial burden, restored splenic CD4(+) T-cell numbers, and increased the frequency of Ehrlichia-specific CD4(+) Th1 cells in comparison to infected WT mice. Although fatal disease is perforin independent, our data suggested that perforin played a critical role in controlling bacterial burden and mediating liver injury. Similar to WT mice, mortality of infected perforin-deficient mice was associated with CD4(+) T-cell apoptosis and a high serum concentration of IL-10. Depletion of IL-10 restored the number of CD4(+) and CD8(+) T cells in infected WT mice. Our data demonstrate a novel mechanism of immunopathology in which CD8(+) T cells mediate Ehrlichia-induced toxic shock, which is associated with IL-10 overproduction and CD4(+) T-cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.00198-07"xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/author | "Walker D.H."xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/author | "Ismail N."xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/author | "Stevenson H.L."xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/author | "Crossley E.C."xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/pages | "4608-4620"xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/title | "Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis."xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/17562770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17562770 |
| http://purl.uniprot.org/citations/17562770 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17562770 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_Q3U543-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_Q62428-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_Q62429-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_Q64333-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_P10820-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_Q3U6V4-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |
| http://purl.uniprot.org/uniprot/#_P21958-mappedCitation-17562770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17562770 |