| http://purl.uniprot.org/citations/17562864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17562864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17562864 | http://www.w3.org/2000/01/rdf-schema#comment | "LINE-1 retrotransposons constitute one-fifth of human DNA and have helped shape our genome. A full-length L1 encodes a 40-kDa RNA-binding protein (ORF1p) and a 150-kDa protein (ORF2p) with endonuclease and reverse transcriptase activities. ORF1p is distinctive in forming large cytoplasmic foci, which we identified as cytoplasmic stress granules. A phylogenetically conserved central region of the protein is critical for wild-type localization and retrotransposition. Yeast two-hybrid screens revealed several RNA-binding proteins that coimmunoprecipitate with ORF1p and colocalize with ORF1p in foci. Two of these proteins, YB-1 and hnRNPA1, were previously reported in stress granules. We identified additional proteins associated with stress granules, including DNA-binding protein A, 9G8, and plasminogen activator inhibitor RNA-binding protein 1 (PAI-RBP1). PAI-RBP1 is a homolog of VIG, a part of the Drosophila melanogaster RNA-induced silencing complex (RISC). Other RISC components, including Ago2 and FMRP, also colocalize with PAI-RBP1 and ORF1p. We suggest that targeting ORF1p, and possibly the L1 RNP, to stress granules is a mechanism for controlling retrotransposition and its associated genetic and cellular damage."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00332-07"xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00332-07"xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Kazazian H.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Kazazian H.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Goodier J.L."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Goodier J.L."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Vetter M.R."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/author | "Vetter M.R."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/pages | "6469-6483"xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/pages | "6469-6483"xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/title | "LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/title | "LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex."xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17562864 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17562864 |
| http://purl.uniprot.org/citations/17562864 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17562864 |